NBI-98782

NBI-98782(alpha-dihydrotetrabenazine)是囊泡单胺转运体（VMAT2）抑制剂，Ki为0.97nM。

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库存: 现货

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数量
2mg

￥1825.00

1460.00

- +
5mg

￥2750.00

2200.00

- +
10mg

￥3900.00

3120.00

- +
50mg

￥11700.00

9360.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce57652
CAS: 85081-18-1
别名: (+)-α-二氢丁苯那嗪; (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ
分子式: C19H29NO3
分子量: 319.44
纯度: >98%
溶解度: DMSO: 33.33 mg/mL (104.34 mM)
储存: Store at -20°C; protect from light
库存: 现货

Background

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM [1]Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection.

[1]. Kilbourn M, et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24;278(3):249-52.