Necrostatin 2 racemate

A RIPK1 inhibitor

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库存: 现货

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数量
1mg

￥812.00

650.00

- +
5mg

￥2175.00

1740.00

- +
10mg

￥3937.00

3150.00

- +
50mg

￥10687.00

8550.00

- +
100mg

￥0.00

0.00

- +
200mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce57664
CAS: 852391-15-2
别名: 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1
分子式: C13H12ClN3O2
分子量: 277.71
纯度: >98%
溶解度: DMSO: ≥ 50 mg/mL (180.04 mM)
储存: Store at -20°C
库存: 现货

Background

(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner.¹ Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS). (±)-Necrostatin-2 decreases irradiation-induced lactate dehydrogenase (LDH) release and cell death in murine embryonic Cyt c^-/- cells.² It also prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine abdominal aortic aneurism (AAA) model at a dose of 1.6 mg/kg/day.

1.Takahashi, N., Duprez, L., Grootjans, S., et al.Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease modelsCell Death Dis.3(11)e437(2012) 2.Huang, Z., Epperly, M., Watkins, S.C., et al.Necrostatin-1 rescues mice from lethal irradiationBiochim. Biophys. Acta1862(4)850-856(2016)