Nicotinamide N-oxide

A metabolite of nicotinamide

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Background

Nicotinamide N-oxide is a metabolite of nicotinamide .¹ It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium , indicating cell differentiation, in HL-60 promyelocytic leukemia cells.² Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.³

1.Real, A.M., Hong, S., and Pissios, P.Nicotinamide N-oxidation by CYP2E1 in human liver microsomesDrug Metab. Dispos.41(3)550-553(2013) 2.Iwata, K., Ogata, S., Okumura, K., et al.Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compoundsBiosci. Biotechnol. Biochem.67(5)1132-1135(2003) 3.Jung, J.Y., Kim, I.Y., Kim, Y.N., et al.1H NMR-based metabolite profiling of diet-induced obesity in a mouse modeBMB Rep.45(7)419-424(2012)