Nimustine hydrochloride

A pyrimidine analog and nitrosourea alkylating agent

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库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥550.00

440.00

- +
10mg

￥875.00

700.00

- +
50mg

￥2725.00

2180.00

- +
100mg

￥4850.00

3880.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.^1,2,3 It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.² Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.³

1.Heal, J.M., Fox, P.L., and Schein, P.S.A structure-activity study of seven new water soluble nitrosoureasBiochem. Pharmacol.28(8)1301-1306(1978) 2.Yoshida, J., Shibuya, N., Kobayashi, T., et al.Sensitivity to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chioroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitroCancer50(3)410-418(1982) 3.Hasegawa, H., Shapiro, W.R., and Posner, J.B.Chemotherapy of experimental metastatic brain tumors in female Wistar ratsCancer Res.39(7 Pt 1)2691-2697(1979)