NP118809

NP118809 是一种有效的 N 型钙通道 (N-type calcium channel) 阻滞剂，IC50 值为 0.11 μM；同时可较弱地抑制 L 型钙通道 (L-type calcium channel)，IC50 值为 12.2 μM。

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库存: 现货

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100mg

￥812.00

650.00

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200mg

￥1012.00

810.00

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500mg

￥1250.00

1000.00

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1g

￥0.00

0.00

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5g

￥0.00

0.00

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已选 0 种 0 瓶

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货号: ajce57774
CAS: 41332-24-5
别名: 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮,39-1B4
分子式: C32H32N2O
分子量: 460.61
纯度: >98%
溶解度: DMSO: 50 mg/mL (108.55 mM); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM. N-Type Ca2+ Channel|0.11 μM (IC50)|L-type calcium channel|12.2 μM (IC50)

NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM[1].

NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model[2].

[1]. Zamponi GW, et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. [2]. Pajouhesh H, et al. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83.