Octanoic acid

A medium-chain saturated fatty acid

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Background

Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.¹ Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC₈₀s = <125, <125, 1,403, and 2,294 μM, respectively).² Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.^3,4 [Matreya, LLC. Catalog No. 1198]

1.Mallatou, H., Pappa, E., and Massouras, T.Changes in free fatty acids during ripening of Teleme cheese made with ewes’, goats’, cows’ or a mixture of ewes’ and goats’ milkInt. Dairy J.13(1-3)211-219(2003) 2.Hyang, C.B., Alimova, Y., Myers, T.M., et al.Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganismsArch. Oral Biol.56(7)650-654(2011) 3.Onkenhout, W., Venizelos, V., van der Poel, P.F.H., et al.Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disordersClin. Chem.41(10)1467-1474(1995) 4.Rinaldo, P., O'Shea, J.J., Coates, P.M., et al.Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycineN. Engl. J. Med.319(20)1308-1313(1988)