Omeprazole D3

An internal standard for the quantification of omeprazole

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库存: 现货

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1mg

￥1825.00

1460.00

- +
5mg

￥7337.00

5870.00

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10mg

￥0.00

0.00

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50mg

￥0.00

0.00

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货号: ajce57854
CAS: 922731-01-9
别名: 奥美拉挫 D3; H 16868-d3
分子式: C17H16D3N3O3S
分子量: 348.43
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Omeprazole-d₃ is intended for use as an internal standard for the quantification of omeprazole by GC- or LC-MS. Omeprazole is a selective and irreversible inhibitor of the gastric H⁺/K⁺ ATPase pump (IC₅₀ = 1.1 μM).¹ It is a racemic mixture of two enantiomers, S-omeprazole and R-omeprazole (sodium salt) , which are prodrugs of the active sulfonamide which is formed by acid-stimulated conversion.^2,3 Both enantiomers are extensively metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4.³

1.Smolka, A.J., Goldenring, J.R., Gupta, S., et al.Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000BMC Gastroenterol.4(4)(2004) 2.Richardson, P., Hawkey, C.J., and Stack, W.A.Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disordersDrugs56(3)307-335(1998) 3.Shi, S., and Klotz, U.Proton pump inhibitors: An update of their clinical use and pharmacokineticsEur. J. Clin. Pharmacol.64(10)935-951(2008)