P110δ-IN-1

ME-401 (P110δ-IN-1, PWT-143) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.

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库存: 现货

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5mg

￥1412.00

1130.00

- +
10mg

￥2400.00

1920.00

- +
50mg

￥8412.00

6730.00

- +
100mg

￥14425.00

11540.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce57906
CAS: 1595129-71-7
别名:
分子式: C31H40N8O3S
分子量: 604.77
纯度: >98%
溶解度: DMSO: 20.83 mg/mL (34.44 mM); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

ME-401 (P110δ-IN-1, PWT-143) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.

ME-401 is an oral, once-daily, selective PI3Kδ inhibitor with an optimized pharmacologic profile that is in clinical development for the treatment of B-cell malignancies. ME-401 can be orally absorbed, distribute to target tissues, enter and accumulate in target cells, and bind to the target with high affinity to exert its mechanism of action.[2]

[1] Ofir Moreno, et al. Clin Ther. 2018 Nov;40(11):1855-1867. [2] Ofir Moreno, Jamie Wood. Target Oncol. 2019 Oct;14(5):603-611.