Phenoxodiol

A phenol with anticancer activity

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥2287.00

1830.00

- +
10mg

￥3775.00

3020.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce58032
CAS: 81267-65-4
别名: 脱氢雌马酚,Idronoxil; Dehydroequol; Haginin E
分子式: C15H12O3
分子量: 240.25
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (416.23 mM); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Idronoxil is a phenol and derivative of genistein that has been found in B. tournefortii and has anticancer activity.^1,2,3 It reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells, but not non-cancerous ovarian surface epithelial (OSE) cells, when used at a concentration of 10 ?g/ml.² Idronoxil (1 ?g/ml) reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells. In vivo, idronoxil (50 and 75 mg/kg) increases latency to tumor formation and reduces tumor multiplicity in a rat model of mammary carcinogenesis induced by dimethylbenz[a]anthracene (DMBA).³

1.Rahmani, R., Bouajila, J., Jouaidi, M., et al.African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals propertiesJ. Food Sci.85(6)1856-1871(2020) 2.Kamsteeg, M., Rutherford, T., Sapi, E., et al.Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cellsOncogene22(17)2611-2620(2003) 3.Constantinou, A.I., Mehta, R., and Husband, A.Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley ratsEur. J. Cancer39(7)1012-1018(2004)