PIM-447 dihydrochloride

PIM447是泛PIM激酶抑制剂，对PIM1，PIM2，PIM3的 Ki 分别为6，18，9 nM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

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促销价

数量
1mg

￥1462.00

1170.00

- +
5mg

￥3987.00

3190.00

- +
10mg

￥6800.00

5440.00

- +
50mg

￥20837.00

16670.00

- +
100mg

￥30450.00

24360.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.

[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20. [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20