Piperaquine tetraphosphate tetrahydrate

An antimalarial agent

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库存: 现货

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促销价

数量
5mg

￥650.00

520.00

- +
10mg

￥987.00

790.00

- +
25mg

￥1962.00

1570.00

- +
50mg

￥3050.00

2440.00

- +
100mg

￥0.00

0.00

- +
200mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce58092
CAS: 915967-82-7
别名: 四磷酸哌喹四水合物
分子式: C29H32Cl2N6.4H3O4P.4H2O
分子量: 999.6
纯度: >98%
溶解度: Water: 6 mg/mL (6.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC₅₀s ranging from 11.8-217.3 nM.¹ Formulations containing piperaquine have been used in combination with artemisinin for the treatment of malaria in HIV-1-positive populations.^2,3,4

1.Akoachere, M., Buchholz, K., Fischer, E., et al.In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisininsAntimicrob. Agents Chemother.49(11)4592-4597(2005) 2.Askling, H.H., Bruneel, F., Burchard, G., et al.Management of imported malaria in EuropeMalar. J.11(2012) 3.Henrich, P.P., O'Brien, C., Sáenz, F.E., et al.Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent modelAntimicrob. Agents Chemother.58(1)183-195(2014) 4.Pascual, A., Parola, P., Benoit-Vical, F., et al.Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparumMalar. J.11(2012)