Piribedil

A dopamine receptor agonist

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库存: 现货

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10mg

￥375.00

300.00

- +
50mg

￥762.00

610.00

- +
100mg

￥887.00

710.00

- +
200mg

￥1212.00

970.00

- +
500mg

￥2437.00

1950.00

- +
1g

￥0.00

0.00

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5g

￥0.00

0.00

- +

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Background

Piribedil is a dopamine receptor agonist.^1,2,3,4 It binds to dopamine D₂, D₃, and D₄ receptors (IC₅₀s = 1-1,000 nM in radioligand binding assays).¹ Piribedil (1 and 10 mg/kg) enhances spontaneous object recognition in young adult rats and attenuates age-related memory impairments in the radial arm maze in mice.² It reduces immobility time in the forced swim test in mice when administered at doses ranging from 0.63 to 10 mg/kg.³ Piribedil (0.3 mg/kg) decreases the number of premature and delayed responses in a response time test, indicating improved attentional function, in a rat model of Parkinson's disease induced by 6-OHDA when administered in combination with L-DOPA .⁴

1.Cagnotto, A., Parotti, L., and Mennini, T.In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic studyEur. J. Pharmacol.313(1-2)63-67(1996) 2.Marighetto, A., Valerio, S., Philippin, J.N., et al.Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodentsJ. Psychopharmacol.22(5)511-521(2008) 3.Brocco, M., Dekeyne, A., Papp, M., et al.Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: Mediation by dopamine D2 receptorsBehav. Pharmacol.17(7)559-572(2006) 4.Turle-Lorenzo, N., Maurin, B., Puma, C., et al.The dopamine agonist piribedil with L-DOPA improves attentional dysfunction: Relevance for Parkinson's diseaseJ. Pharmacol. Exp. Ther.319(2)914-923(2006)