QL47

QL47不可逆的BTK抑制剂，IC50为7 nM。

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库存: 现货

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促销价

数量
2mg

￥1212.00

970.00

- +
5mg

￥1825.00

1460.00

- +
10mg

￥2775.00

2220.00

- +
50mg

￥10775.00

8620.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce58338
CAS: 1469988-75-7
别名:
分子式: C27H21N5O2
分子量: 447.49
纯度: >98%
溶解度: Water: < 0.1 mg/mL (insoluble); DMSO: < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.IC50 Value: 7 nMTarget: Btkin vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].in vivo: N/A

[1]. Wu, H., et al., Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma. ACS Chem Biol, 2014.