Quilseconazole (VT-1129) 是一种有效、可口服的真菌 Cyp51 (fungal Cyp51) 抑制剂,能够与隐球菌的 Cyp51 紧密结合,但对人 Cyp51 的抑制作用很弱。
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Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1]. Fungal, Cyp51[1]
[1]. Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.
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