Uridine triphosphate trisodium salt

A nucleotide and dual P2Y2 and P2Y4 receptor agonist

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100mg

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货号: ajce59976
CAS: 19817-92-6
别名: 尿苷-5'-三磷酸三钠盐
分子式: C9H12N2Na3O15P3
分子量: 550.09
纯度: >98%
溶解度: Water: 110 mg/mL (199.97 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

Uridine 5'-triphosphate (UTP) is a nucleotide and dual agonist of purinergic P2Y₂ and P2Y₄ receptors (EC₅₀s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors).^1,2 It is selective for P2Y₂ and P2Y₄ receptors over P2Y₆ receptors (EC₅₀ = >10,000 nM).² UTP stimulates proliferation of PANC-1 cells (EC₅₀ = 13.1 μM), an effect that can be prevented by siRNA against the P2Y₂ receptor.¹ It induces vasoconstriction in perfused isolated canine epicardial coronary artery in a concentration-dependent manner.³ UTP is formed from uridine monophosphate (UMP) by two sequential phosphorylations and can be converted to cytidine 5'-triphosphate .⁴ It also reacts with glucose-1-phosphate to form UDP-glucose , a precursor in the biosynthesis of glycogen.⁵

1.Choi, J.H., Ji, Y.G., and Lee, D.H.Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptorPancreas42(4)680-686(2013) 2.Maruoka, H., Jayasekara, M.P.S., Barrett, M.O., et al.Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y4 receptorJ. Med. Chem.54(12)4018-4033(2011) 3.Matsumoto, T., Nakane, T., and Chiba, S.UTP induces vascular responses in the isolated and perfused canine epicardial coronary artery via UTP-preferring P2Y receptorsBr. J. Pharmacol.122(8)1625-1632(1997) 4.Berg, J.M., Tymoczko, J.L., and Stryer, L.In de novo synthesis, the pyrimidine ring is assembled from bicarbonate, aspartate, and glutamineBiochemistry(2002) 5.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002)