β-Zearalenol

A hepatic metabolite of zearalenone

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数量
500ug

￥600.00

480.00

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1mg

￥900.00

720.00

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5mg

￥1487.00

1190.00

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10mg

￥2750.00

2200.00

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货号: ajce60258
CAS: 71030-11-0
别名: Β-玉米赤霉烯醇,β-trans-Zearalenol, (-)-β-Zearalenol
分子式: C18H24O5
分子量: 320.38
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.1 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C,protect from light
库存: 现货

Background

β-Zearalenol is a hepatic metabolite of zearalenone , a mycotoxin produced by fungi in food and animal feeds.^1,2 It is a less potent agonist of estrogen receptors than the parent compound.³ However, β-zearalenol has pronounced effects on uterotropic activity and sperm acrosome reaction.^4,5,6

1.Zinedine, A., Soriano, J.M., Moltó, J.C., et al.Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxinFood Chem. Toxicol.45(1)1-18(2007) 2.Ueno, Y., and Tashiro, F.α-Zearalenol, a major hepatic metabolite in rats of zearalenone, an estrogenic mycotoxin of Fusarium speciesJ. Biochem.89(2)563-571(1981) 3.Kiang, D.T., Kennedy, B.J., Pathre, S.V., et al.Binding characteristics of zearalenone analogs to estrogen receptorsCancer Res.38(11 Pt 1)3611-3615(1978) 4.Mirocha, C.J., Pathre, S.V., Behrens, J., et al.Uterotropic activity of cis and trans isomers of zearalenone and zearalenolAppl. Environ. Microbiol.35(5)986-987(1978) 5.Filannino, A., Stout, T.A.E., Gadella, B.M., et al.Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion spermReprod. Biol. Endocrinol.9134(2011) 6.Wang, H., Camargo Rodriguez, O., and Memili, E.Mycotoxin α-zearalenol impairs the quality of preimplantation porcine embryosJ. Reprod. Dev.58(3)338-343(2012)