Emodin-8-glucoside

An anthraquinone glycoside with diverse biological activities

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1mg

￥575.00

460.00

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5mg

￥1737.00

1390.00

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10mg

￥2950.00

2360.00

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Background

Emodin 8-glucoside is an anthraquinone glycoside that has been found in R. japonica and has diverse biological activities.^1,2,3,4 It inhibits the activities of rat lens aldose reductase and human DNA topoisomerase II (IC₅₀s = 14.4 and 66 μM, respectively, in cell-free assays).^1,2 Emodin 8-glucoside (1 ng/ml) promotes the proliferation and differentiation of mouse MC3T3-E1 osteoblastic cells.³ It also decreases infarct size in a rat model of focal cerebral ischemia and reperfusion injury when administered at a dose of 5 mg/kg.⁴

1.Kim, J.M., Jamg, D.S., Lee, Y.M., et al.Constituents of the fruits of Rumex japonicus with inhibitory activity on aldose reductaseJ. Appl. Biol. Chem.51(1)13-16(2008) 2.Hwangbo, K., Zheng, M.S., Kim, Y.-J., et al.Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonicaArch. Pharm. Res.35(9)1583-1589(2012) 3.Xiang, M.-X., Xu, Z., Su, H.-W., et al.Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cellsMolecules16(1)728-737(2011) 4.Wang, C., Zhang, D., Ma, H., et al.Neuroprotective effects of emodin-8-O-β-D-glucoside in vivo and in vitroEur. J. Pharmacol.577(1-3)58-63(2007)