Trifolirhizin

A flavonoid with anticancer and vasorelaxant activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥550.00

440.00

- +
5mg

￥1087.00

870.00

- +
10mg

￥1825.00

1460.00

- +
20mg

￥3112.00

2490.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Trifolirhizin is a flavonoid that has been found in S. flavescens and has anticancer and vasorelaxant activities.^1,2 It induces the accumulation of LC3 puncta, a marker of autophagy, in HCT116 and SW620 cells, as well as inhibits proliferation of B16/F10 murine melanoma and human A2780 ovarian and MKN45 gastric cancer cells when used at a concentration of 20 ?M.¹ Trifolirhizin (10 m/kg) induces intratumor apoptosis and necrosis and reduces tumor weight and volume in a colorectal cancer mouse xenograft model. It also induces relaxation in precontracted isolated mouse aortic rings in a β₂-adrenergic receptor-independent manner when used at concentrations ranging from 0.2 to 20 ?g/ml.²

1.Sun, D., Tao, W., Zhang, F., et al.Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signalingSignal Transduct. Target. Ther.5(1)174(2020) 2.Yang, N., Liang, B., Srivastava, K., et al.The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contractionPhytochemistry95259-267(2013)