Ginkgolide J

A terpene trilactone with diverse biological activities

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库存: 现货

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数量
1mg

￥987.00

790.00

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5mg

￥2925.00

2340.00

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10mg

￥4925.00

3940.00

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货号: ajcn5464
CAS: 107438-79-9
别名: 银杏内酯J
分子式: C20H24O10
分子量: 424.4
纯度: >98%
溶解度: DMF: 10mg/mL,DMSO: 25mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 10mg/mL
储存: Store at -20°C
库存: 现货

Background

Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. ^1,2,3 It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC₅₀s = 27 and 43.5 μg/ml, respectively).² Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.³

1.Braquet, P., Esanu, A., Buisine, E., et al.Recent progress in ginkgolide researchMed. Res. Rev.11(3)295-355(1991) 2.Koch, E.Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: Considerations on possible bleeding complications after oral intake of Ginkgo biloba extractsPhytomedicine12(1-2)10-16(2005) 3.Vitolo, O., Gong, B., Cao, Z., et al.Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide JNeurobiol. Aging30(2)257-265(2009)