Artemisinine

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20mg

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Extracted from Artemisia annua L.;Suitability:Acetone,benzene,chloroform,ethyl acetate and acetic acid;Store the product in sealed,cool and dry condition

货号：ajcn5536
CAS：63968-64-9
分子式：C15H22O5
分子量：282.33
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells[1]. Artemisinin (1-100?μM; 24? hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30?±?0.73?μM in UMRC-2 cells and 23.97?±?0.92 CAKI-2 cells[2]. Artemisinin (25, 50?μM; 24?hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner[2].

Artemisinin (gavage; 20?mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth[2].

参考文献:
[1]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.
[2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.