1,4-Dicaffeoylquinic acid

1,4-Dicaffeoylquinic acid (1,4-DCQA) 是一种来自苍耳子的苯丙素，可抑制 LPS 刺激的 TNF-α 产生。

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5mg

￥5425.00

4340.00

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10mg

￥9250.00

7400.00

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Background

1,4-Dicaffeoylquinic acid is a polyphenol that has been found in C. coronarium and has diverse biological activities.^1,2,3,4 It scavenges DPPH radicals and inhibits xanthine oxidase (XO; IC₅₀ = 7.36 ?M).^1,2 1,4-Dicaffeoylquinic acid (25 ?M) decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16/F1 murine melanocytes, inhibits melanogenesis in the same cells, and decreases tyrosinase activity in B16/F1 cell lysates.³ It increases biliary flow in rats in a dose-dependent manner.⁴

1.Alberati, D., Moreau, J.-L., Lengyel, J., et al.Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophreniaNeuropharmacology62(2)1152-1161(2012) 2.Cao, W., Fang, Y., Wu, T., et al.Insights from multispectral and molecular docking investigation on the xanthine oxidase inhibition by 1,4-dicaffeoylquinic acidJ. Mol. Struct.1219128475(2020) 3.Ha, J.H., and Park, S.N.Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studiesBioorg. Med. Chem.26(14)4201-4208(2018) 4.Preziosi, P., Loscalzo, B., and Marmo, E.Comparison of choleretic effects of CYN and Na-dehydrocholateExperientia15(4)135-138(1959)