Germacrone

A sesquiterpene with diverse biological activities

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库存: 现货

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数量
1mg

￥375.00

300.00

- +
5mg

￥550.00

440.00

- +
10mg

￥987.00

790.00

- +
20mg

￥1625.00

1300.00

- +

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货号: ajcn5750
CAS: 6902-91-6
别名: 吉马酮
分子式: C15H22O
分子量: 218.33
纯度: >98%
溶解度: DMF: 20mg/mL,DMF:PBS (pH 7.2) (1:8): 0.11mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL
储存: 4°C, protect from light
库存: 现货

Background

Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.^1,2,3,4 It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 ?M.¹ Germacrone (50-250 ?M) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells.² In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.³ It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).⁴

1.He, W., Zhai, X., Su, J., et al.Antiviral activity of germacrone against pseudorabies virus in vitroPathogens8(4)E258(2019) 2.Xie, X.-H., Zhao, H., Hu, Y.-Y., et al.Germacrone reverses adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cellsExp. Ther. Med.8(5)1611-1615(2014) 3.Guo, Y.-R., and Choung, S.-Y.Germacrone attenuates hyperlipidemia and improves lipid metabolism in high-fat diet-induced obese C57BL/6J miceJ. Med. Food20(1)46-55(2017) 4.Wu, T., Yin, F., Kong, H., et al.Germacrone attenuates cerebral ischemia/reperfusion injury in rats via antioxidative and antiapoptotic mechanismsJ. Cell. Biochem.120(11)18901-18909(2019)