Anti-Inflammatory Peptide 1

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数量
5mg

￥709.00

638.00

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10mg

￥1087.00

978.00

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25mg

￥1367.00

1230.00

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PLA2 inhibitor

货号：ajcp4490
CAS：118850-71-8
分子式：C45H82N12O14S2
分子量：1079.33
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Anti-Inflammatory Peptide 1 (C45H82N12O14S2), with the sequence H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH, belongs to the group of synthetic oligopeptides corresponding to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I. The name 'antiflammins' is proposed for those peptides, which are valuable models for the development of novel anti-inflammatory agents of therapeutic importance. Anti-inflammatory peptide 1 possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), whose increased presence and activity results in inflammation and pain at certain bodily sites.

参考文献:
1. Argiolas A, Pisano JJ (November 1983). "Facilitation of phospholipase A2 activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom". J. Biol. Chem. 258 (22): 13697–702.