Myelin Basic Protein (87-99)

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
1mg

￥898.00

808.00

- +
5mg

￥2308.00

2077.00

- +
10mg

￥4097.00

3687.00

- +
25mg

￥5571.00

5013.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Encephalitogenic peptide

货号：ajcp4502
CAS：118506-26-6
分子式：C74H114N20O17
分子量：1555.8
纯度：98%
存储：Store at -20°C
库存：现货

Background:

The basic protein is a major structural protein of the central nervous system myelin in which it constitutes 30% of the total protein.(1)
T lymphocyte cell lines selected with whole MBP typically recognize only 1-3 immunodominant epitopes (Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al., 1988; McCarron and McFarlin, 1988) and these immunodominant MBP epitopes frequently are cncephalitogenic (Vandenbark et al., 1985b, 1989; Hashim et al., 1991). Thus, the identification of immunodominant MBP epitopes is likely to provide an in vitro method of identifying unrecognized enccphalitogenic epitopes of MBP. (2)
Although the cause of multiple sclerosis (MS) is not known, a T cell-mediated autoimmune process has been postulated. Myelin basic protein (MBP) is a potential target antigen because it induces experimental allergic encephalomyelitis (EAE) in susceptible animals. Encephalitogenic epitopes of MBP differ among susceptible strains and correlate with the MHC class II genotype. (3)

参考文献:
1. EYLAR, E. H., in L.Rowland (Editor), Immunologic disorders of the nervous system, Academic Press, New York, 1971, Chapter 5.
2. Jones et al (1992) the synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203
3. Fritz, R., and D.E. McFarlin . 1989. Encephalitogenic epitopes 10. Richert, J., E.D. Robinson, G.E . Deibler, R.E. Martenson, of myelin basic protein. Chem. Immunol. 46:101.