MASM7

MASM7 是一种 mitofusin 激活剂，可通过 mitfusins 实现线粒体融合。MASM7 可浓度响应性增加 Mito AR，在MEFs 细胞中 EC50 值为 75 nM，并可通过直接激活 MFN2 或 MFN 促进线粒体融合。MASM7 还可与 MFN2 的 HR2 结构域直接结合，其 Kd 值为 1.1 μM。

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库存: 现货

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1mg

￥987.00

790.00

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5mg

￥2437.00

1950.00

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10mg

￥3887.00

3110.00

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Background

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM^[1].

MASM7 (1-10 μM, 2 h) increases Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN^[1].
MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM^[1].
MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines^[1].
MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h^[1].
MASM7 (1 μμ, 6 h) does not induce caspase-3/7 activation in U2OS cells^[1].
MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs^[1].