2,4,6-Trihydroxybenzaldehyde

2,4,6-Trihydroxybenzaldehyde 是一种具有口服活性的 NF-?B 抑制剂。2,4,6-Trihydroxybenzaldehyde 具有抗肿瘤活性、抗癌细胞增殖活性和抗肥胖活性。

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库存: 现货

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10mg

￥812.00

650.00

- +
25mg

￥1375.00

1100.00

- +
50mg

￥1937.00

1550.00

- +
100mg

￥2900.00

2320.00

- +
500mg

￥8100.00

6480.00

- +

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Background

2,4,6-Trihydroxybenzaldehyde is an orally active NF-?B inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity^[1]^[2]^[3].

2,4,6-Trihydroxybenzaldehyde inhibits adipocyte differentiation and lipid accumulation in 3T3-L1 cells^[1].
2,4,6-Trihydroxybenzaldehyde down-regulates PPARγ, C/EBPα, SREBP-1c, and FAS protein expression levels^[1].

2,4,6-Trihydroxybenzaldehyde (oral administration; 5 and 25 mg/kg for 13 weeks) reduces the HFD-induced increase in weight gain, reduces serum levels of glucose, triglycerides, and total cholesterol^[1].

[1]. Kim KN, et al. 2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice. Environ Toxicol Pharmacol. 2015 Mar;39(2):962-8.
[2]. Marton A, et al. Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF?B Activation and Suppress Growth of A375 Human Melanoma. Anticancer Res. 2016 Nov;36(11):5743-5750.
[3]. Forester SC, et al. Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells. J Agric Food Chem. 2010 May 12;58(9):5320-7.