N-Ethylmaleimide-d5

N-Ethylmaleimide-d5 是 N-Ethylmaleimide 的氘代物。N-Ethylmaleimide (NEM)，烷基化自由巯基的试剂，是一种半胱氨酸蛋白酶抑制剂。N-Ethylmaleimide 特异性抑制线粒体中的磷酸盐转运。N-Ethylmaleimide 同样也是一种去泛素化酶 (deubiquitinating enzyme) 抑制剂。

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库存: 现货

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5mg

￥5762.00

4610.00

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10mg

￥9287.00

7430.00

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货号: ajcf20792
CAS: 360768-37-2
别名: NEM-d<sub>5</sub>
分子式: C6H2D5NO2
分子量: 130.16
纯度: >98%
溶解度: DMSO : 100 mg/mL (768.29 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

N-Etlmaleimide-d₅ is the deuterium labeled N-Etlmaleimide. N-Etlmaleimide (NEM), a reagent that alkylates free sulfdryl groups, is a cysteine protease inhibitor[1]. N-etlmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Etlmaleimide is also a deubiquitinating enzyme inhibitor[3].

Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].