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ATG4B (human recombinant)
Autophagy-related 4B (ATG4B), also known as autophagin-1, is a cysteine protease and a member of the C54 protease family with dual roles in the progression of autophagy.
SenTraGor? Cell Senescence Reagent
A cellular senescence detection reagent
TFEB activator 1
A synthetic curcuminoid and activator of TFEB
Verucopeptin
Verucopeptin 是一种有效的 HIF-1 (IC50=0.22 μM) 抑制剂,可以降低 HIF-1 靶基因的表达和 HIF-1α 的蛋白水平。通过直接靶向 v-ATPase ATP6V1G 亚基 (但不靶向 ATP1V1B2 或 ATP6V1D),Verucopeptin 强烈抑制 v-ATPase 活性。Verucopeptin 对耐药性癌细胞表现出抗肿瘤活性,常用作癌症相关研究。
CA77.1
CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
BL-918
An ULK1 activator
5-Heneicosylresorcinol
An alkylresorcinol
J22352
J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂,其IC50值为4.7nM,J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果,并通过降低PD-L1的免疫抑制活性,使宿主抗肿瘤活性恢复。
EACC
EACC 是可逆的自噬 (autophagy) 抑制剂,可阻断自噬通量。EACC 选择性抑制自噬体特异性的 SNARE Stx17 的易位,从而阻止自噬体与溶酶体的融合。
GW406108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases
AC-73
AC-73是ClusterofDifferentiation147(CD147)的第一种特定的口服生物利用的抑制剂,可特异性破坏CD147的二聚化(结合位点在CD147的N端IgC2域中包括Glu64和Glu73),从而抑制CD147/ERK1/2/STAT3/MMP-2途径,并抑制肝癌细胞的运动和侵袭。AC-73还是一种抗增殖药,也是白血病细胞自噬的诱导剂。
Dopamine-d4 (hydrochloride)
An internal standard for the quantification of dopamine
(E/Z)-4-hydroxy Tamoxifen-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
Metformin D6 hydrochloride
An internal standard for the quantification of metformin
Valechlorine
Valechlorine,一种自噬增强剂,可分解脂滴。Valechlorine 以 Atg5 依赖性方式减少油酸 (OA) 诱导的脂质蓄积。