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Pimasertib (AS-703026)
A MEK1/2 inhibitor
Methylnissolin
A flavonoid with antiproliferative activity
PLX8394
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
(S)-p38 MAPK Inhibitor III
A cell-permeable p38 MAP kinase inhibitor
ITX5061
ITX5061是一个II型p38MAPK抑制剂,也是清道夫受体B1(SR-B1)的拮抗剂。
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inf
PF-06260933
A MAP4K4 inhibitor
TCS JNK 6o
A JNK inhibitor
U-0126
A MEK inhibitor and AMPK activator
PD 198306
A potent inhibitor of MEK1/2
NQDI 1
A selective inhibitor of ASK1
Cobimetinib
A potent, orally available MEK1 inhibitor
DIPQUO
DIPQUO 是一种骨标记碱性磷酸酶 (ALP) 激活剂,在 C2C12 细胞中作用的 EC50 值为 6.27 μM。DIPQUO 通过激活 p38 MAPK-β 促进小鼠和人类的成骨细胞分化。
BAY885
ZM336372
An activator of the Raf-1 signalling pathway