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Lazertinib
An irreversible inhibitor of mutant EGFRs
SU5408 (VEGFR2 Kinase Inhibitor I)
A potent, cell-permeable inhibitor of VEGFR2
AZD9291(Osimertinib)
PIM447
PIM447 (LGH447) 是一种有效的、口服的、选择性的泛 PIM 激酶抑制剂,对 PIM1、PIM2 和 PIM3 的 Ki 值分别为 6、18 和 9 pM。 PIM447 具有双重抗骨髓瘤和骨保护作用。 PIM447 诱导细胞凋亡。
Pelitinib (EKB-569)
An EGFR receptor tyrosine kinase inhibitor
Semilicoisoflavone B
Semilicoisoflavone B,一种异黄酮,主要来源于 Glycyrrhiza uralensis Fisch.。Semilicoisoflavone B 通过抑制 β-分泌酶-1 (BACE1) 的表达和活性来减少淀粉样蛋白 β (amyloid β,Aβ) 的分泌。Semilicoisoflavone B 主要通过增加 PPARγ 表达和抑制 STAT3 磷酸化来降低 BACE1 的表达。
Erlotinib
An EGFR tyrosine kinase inhibitor
C188-9
A STAT3 inhibitor
Dilmapimod (SB-681323)
Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
ZM 323881 HCl
A potent and selective VEGFR2 inhibitor
TAS6417
TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.
Talmapimod (SCIO-469)
A p38 MAPK inhibitor
AV-412
A dual inhibitor of EGFR and HER2
Afatinib dimaleate
An inhibitor of EGFR and ErbB2
TP-3654
A Pim kinase inhibitor