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Brevilin A
Isorhapontigenin
GNE0877
A selective LRRK2 inhibitor
EN6
An activator of autophagy
CZC-25146
A potent LRRK2 inhibitor
JH-II-127
An inhibitor of wild-type and mutant forms of LRRK2
Pennogenin 3-O-beta-chacotrioside
Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
ERK5-IN-1
An ERK5 inhibitor
MLi-2
An LRRK2 inhibitor
3'-Hydroxypterostilbene
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue,
Glycycoumarin
Glycycoumarin 是一种甘草中主要的生物活性香豆素。Glycycoumarin 通过激活自噬,抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径,来抑制肝细胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。
OSU-T315
OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
PF-06447475
PF-06447475 是一种高效、选择性和脑渗透性 LRRK2 抑制剂,IC50 为 3 nM。
GNE-9605
Actein
Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖,诱导自噬和凋亡。Actein 在体内几乎没有毒性。