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Z-VAD-FMK
Z-VAD-FMK(Z-Val-Ala-Asp(OMe)-FMK)是一种可渗透细胞并且不可逆的泛caspase抑制剂。 Z-VAD-FMK也是一种泛素羧基末端水解酶L1(UCHL1)抑制剂。 Z-VAD-FMK通过针对UCHL1的活性位点,使其发生不可逆修饰,从而起到作用。
Emricasan
A pan-caspase inhibitor
Gardenin B
Gardenin B 是从 Baccharis scandens 中分离出的一种黄酮类化合物。Gardenin B 能诱导人白血病细胞死亡,诱导的凋亡发生与多个 caspases 相关。
Thevetiaflavone
Thevetiaflavone 可以上调 Bcl?2 的表达,下调 Bax 和 caspase-3 的表达。
Eupatorin
A flavonoid with diverse biological activities
Arnicolide D
A sesquiterpene lactone with anticancer activity
Phenoxodiol
A phenol with anticancer activity
Z-LLE-AMC
A fluorogenic substrate for proteasomal caspase-like activity
Ac-DEVD-CHO
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
Biotin-VAD-FMK
A biotin-conjugated pan-caspase inhibitor
Ginsenoside Rh4
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
Tomatine
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
Tauroursodeoxycholate (TUDCA)
A taurine-conjugated form of ursodeoxycholic acid
PAC-1
An in vitro procaspase-3 activator
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。