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Trilaciclib (G1T28)
CDK4/6-IN-2
CDK4/6-IN-2 是一种有效的 CDK4 和 CDK6 抑制剂,IC50 分别为 2.7 和 16 nM,详细信息请参考专利文献 US20180000819A1 中 的化合物 1。
Ribociclib succinate hydrate
Ribociclib (LEE011) succinate (Kisqali) is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.
CDK4 inhibitor
An antiproliferative cyclin D1/Cdk4 inhibitor
PF-06873600
An inhibitor of Cdk2, Cdk4, and Cdk6
Cucurbitacin D
A triterpenoid with diverse biological activities
LDC4297
A CDK7 inhibitor
PHA-767491
A potent Cdc7 kinase inhibitor
Indirubin-5-sulfonate
Indirubin-5-sulfonate 是周期蛋白依赖性激酶(CDK) 的抑制剂,对CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E、CDK4/cyclin D1 和CDK5/p35 的IC50 值分别为55 nM、35 nM、150 nM、300 nM 和 65 nM。Indirubin-5-sulfonate 同样能抑制GSK-3β 的活性。
(-)-BAY-1251152
A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152
Ro 3306
An inhibitor of Cdk1
PHA-767491 hydrochloride
Senexin A
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.
Senexin B
An inhibitor of Cdk8 and Cdk19
Indirubin-3'-monoxime-5-sulphonic acid
Indirubin-3'-monoxime-5-sulphonic acid 是一种有效选择性的 CDK1,CDK5,GSK-3β 抑制剂,对应的 IC50 值分别为 5 nM,7 nM,80 nM。