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Lazertinib
An irreversible inhibitor of mutant EGFRs
SU5408 (VEGFR2 Kinase Inhibitor I)
A potent, cell-permeable inhibitor of VEGFR2
AZD9291(Osimertinib)
Pelitinib (EKB-569)
An EGFR receptor tyrosine kinase inhibitor
Erlotinib
An EGFR tyrosine kinase inhibitor
ZM 323881 HCl
A potent and selective VEGFR2 inhibitor
TAS6417
TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.
AV-412
A dual inhibitor of EGFR and HER2
Afatinib dimaleate
An inhibitor of EGFR and ErbB2
PD168393
An irreversible EGFR kinase inhibitor
BMS-599626 Hydrochloride
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂,IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍,对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖,并有可能增加肿瘤对放疗的反应。
Mutated EGFR-IN-1
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
Dovitinib (TKI258) Lactate
A multi-kinase inhibitor
N-Desethyl Sunitinib
An active metabolite of sunitinib
Lapatinib
A dual inhibitor of EGFR and ErbB2