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C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inf
PLX8394
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
ZM336372
An activator of the Raf-1 signalling pathway
Anthraflavic acid
2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity.
AD80
AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
Furafylline
Furafylline, as a long-acting replacement for theophylline in the treatment of asthma, is a methylxanthine derivative[1].
Isomerazin
A coumarin with antioxidant and anti-inflammatory activities
Retro-2
A selective inhibitor of retrograde protein trafficking mediated by syntaxin-5
RAF mutant-IN-1
RAF mutant-IN-1 是RAF kinase 的抑制剂,信息来自专利WO2019107987A1,对C-RAF 340D/Y341D、B-RAFV600E 和B-RAFWT 的IC50 值分别为 21 nM、30 nM和392 nM。
HG6-64-1
HG6-64-1是有效选择性的B-Raf抑制剂, 来自专利专利WO 2011090738 A2,化合物实例9 (XI-1)。在B-raf V600E转化的Ba/F3细胞中IC50值为0.09 μM。
Draflazine
Draflazine (R-75231) 是一种 ENT1 抑制剂。Draflazine (R-75231) 在 CFA 机械痛觉过敏模型,热力学和机械痛觉过敏的卡拉胶炎症模型中完全逆转了超敏反应。
MLN 2480
An oral pan-Raf kinase inhibitor
Sorafenib (D3)
An internal standard for the quantification of sorafenib
Sorafenib (D4)
Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂,抑制 Raf-1,B-Raf 和 VEGFR-3 的 IC50 分别为6 nM,20 nM,22 nM。
LY3009120
A pan-Raf and Raf dimer inhibitor