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信号通路
Cell Cycle/DNA Damage
Aurora Kinase
HSP (Heat shock proteins)
HDAC (Histone deacetylases)
Deubiquitinase
Casein Kinase
Checkpoint Kinase (Chk)
NA-PKcs (DNA-dependent protein kinase, catalytic subunit)
DNA/RNA Synthesis
CDK
ATM/ATR
Antifolate
DNA Alkylator/Crosslinker
PI3K/Akt/mTOR
PTEN (Phosphatase and tensin homologue deleted on chromosome 10)
mTOR (mammalian target of Rapamycin)
MELK (Maternal embryonic leucine zipper kinase)
Glycogen synthase kinase 3 (GSK-3)
PI3K (Phosphoinositide 3-kinase)
Akt/PKB (Protein kinase B)
PDK-1 (phosphoinositide dependent protein kinase-1)
Epigenetics
Histone Methyltransferase
Janus kinase (JAK)
PARP
PKC (Protein kinase C)
AMPK
Sirtuin (Sir2 proteins)
DNA Methyltransferase
Epigenetic Reader Domain
Apoptosis(all)
MDM-2/p53
Apoptosis
RIP kinase
Bcl-2 Family
Ferroptosis
Caspase
TNF Receptor
PKD (Protein kinase D)
DAPK
FKBP (FK506-binding protein)
GPCR/G Protein
Angiotensin Receptor
Cannabinoid Receptor
5-HT Receptor
Adenosine Receptor
Adrenergic Receptor
CCR (Chemokine receptors)
CXCRs (CXC chemokine receptors)
Endothelin Receptor
MAPK/ERK Pathway
MEK
p38 MAPK
Raf
ERK
JNK/JNKs (c-Jun N-terminal kinases)
Ribosomal S6 Kinase (RSK)
MAP3K/MAP4K
Cytoskeleton
Microtubule/Tubulin
Monopolar spindle 1 (Mps1)
Integrin
PAKs (p21-activated kinases)
Gap Junction Protein
Kinesin
Arp2/3 Complex
Anti infection
Bacterial
HBV
HIV
HCV
Influenza virus
HSV
RSV (Respiratory syncytial virus)
Parasite
Membrane Transporter/Ion Channel
iGluR (ionotropic glutamate receptor)
GABA Receptor
Calcium Channel
CFTR (Cystic fibrosis transmembrane conductance regulator)
nAChR/nAChRs (nicotinic acetylcholine receptors)
Na+/K+-ATPase
ATP Synthase
Chloride Channel
BCRP(breast cancer resistant protein)
Protein Tyrosine Kinase/RTK
FGFR (Fibroblast growth factor receptors)
ALK (Anaplastic lymphoma kinase)
c-Met (hepatocyte growth factor receptor, HGFR)
Bcr-Abl
c-Kit
FAK (Focal Adhesion Kinase or PTK2)
Bruton tyrosine kinase (Btk)
FLT3 (Fms-like tyrosine kinase 3, CD135)
c-FMS (CSF1R, CSF-1R)
DYRK
IGF-1R (Insulin-like growth factor 1 receptor)
Discoidin Domain Receptor
JAK/STAT Signaling
EGFR
Pim kinases
STAT
NF-κB(all)
NF-κB
IKK (IκB kinase)
Keap1-Nrf2
Reactive oxygen species (ROS)
Immunology/Inflammation
Arginase
NO Synthase
Cyclooxygenase (COX)
Aryl Hydrocarbon Receptor
Interleukin-1 receptor-associated kinase (IRAK)
PD-1/PD-L1
Complement System
NOD-like Receptor (NLR)
Interleukin Related
Neuronal Signaling
Dopamine Receptor
GPR119
Beta-secretase (BACE)
Cholecystokinin Receptor
FAAH (Fatty acid amide hydrolase)
Ca2+/calmodulin-dependent kinase (CaMK)
Acetylcholinesterase (AChE or acetylhydrolase)
Dopamine Transporter
Amyloid-β
Catechol O-methyltransferase (COMT)
Stem Cell/Wnt
Wnt
Notch
Hedgehog (Hh)
ROCK
Autophagy(all)
Leucine-rich repeat kinase 2 (LRRK2)
Autophagy
ULK1/ULK2
TGF-beta/Smad
Transforming growth factor-beta (TGF-beta)
PROTAC
E3 Ligase Ligand-Linker Conjugate
SNIPER
Ligand for Target Protein for PROTAC
Antibody-drug Conjugate/ADC Related
Metabolic Enzyme/Protease
Aldose Reductase
Aldehyde Dehydrogenase (ALDH)
Angiotensin-converting Enzyme (ACE)
Cathepsin
Aminopeptidase
ATP Citrate Lyase
5 alpha Reductase
Acyltransferase
Aminoacyl-tRNA Synthetase
Acetyl-CoA carboxylase (ACC)
Carbonic Anhydrase
Others
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